The ethical treatment of cancer patientsparticipating in clinical trials requiresthat patients are well-informed about thepotential benefits and risks associated withparticipation. When patients enrolled in phaseI clinical trials report that their chance ofbenefit is very high, this is often taken as evidence of a failure of the informed consent process. We argue, however, that some simple themes from the philosophy of language may make such a conclusion less certain. First, the patient may receive conflicting statements from multiple speakers about the expected (...) outcome of the trial. Patients may be reporting the message they like best. Second, there is a potential problem of multivocality. Expressions of uncertainty of the frequency type can be confused with expressionsof uncertainty of the belief type. Patients may be informed using frequency-type statements and respond using belief-type statements. Third, each speech episode involving the investigator and the patient regarding outcomes may subservemultiple speech acts, some of which may beindirect. For example, a patient reporting ahigh expected benefit may be reporting a beliefabout the future, reassuring family members,and/or attempting to improve his or her outcome by apublic assertion of optimism. These sources oflinguistic confusion should be considered injudging whether the patient's reported expectation isgrounds for a bioethical concern that there hasbeen a failure in the informed consent process. (shrink)

The superfluid state of fermion-antifermion fields developed in our previous papers is generalized to include higher orbital and spin states. In addition to single-particle excitations, the system is capable of having real and virtual bound or quasibound composite excitations which are akin to bosons of spinJ P equal to0 −, 1−, 2+, etc. These pseudoscalar, vector, and tensor bosons can be massive or massless and provide the vehicles for strong, electromagnetic, weak, and gravitational interactions. The concept that the basic (unmanifest) (...) fermion-antifermion interaction can lead to a multiplicity of manifest interactions seems to provide a basis for a unified field theory. (shrink)

A new model for the aether is suggested according to which it is a superfluid state of fermion and antifermion pairs, describable by a macroscopic wave function. The vacuum state of this superfluid pervades the entire universe and may account for the missing matter. The visible matter in the universe appears as excitations from the underlying superfluid vacuum.

This edition is apparently a facsimile reproduction of Andrew Motte's translation of 1729, but no acknowledgment is given. It contains a brief biographical introduction by Alfred Del Vecchio. It omits Newton's prefaces and that of Cotes to the second edition, the latter being of value to those interested in the conflict between Newton's views and those of Descartes. Neither index nor table of contents are provided. In short, a not very helpful edition.—K. P. F.

Statʹi, razmyshlenii︠a︡, ocherki -- Pisʹma v redakt︠s︡ii -- Perepiska s chlenami Soi︠u︡za svobodomysli︠a︡shchikh -- Pisʹma k M.I. Barskoĭ -- Perepiska mezhdu K.P. Krizhanovskim i I.G. Khusidom -- Iz materialov dela K.P. Krizhanovskogo.

In this essay, a Jewish thinker argues that the world as depicted by science forms a single system: each part is related to all because all are related to a single knower; this single system constitutes a whole which has priority over its parts because it conditions or delimits their behavior. This totality is the unchanging source of all processes, all making actual what had been merely possible. This totality Kohn attempts to define as God, and, taking it for granted (...) that science depicts the universe as undergoing continuous evolution on the whole and within its parts, he attempts to show how such evolution reveals, in the human perspective, that God is creativity. He distinguishes three "levels of being" produced in the course of the cosmic evolution--inorganic matter, sensitivity, conscience--but denies that the arising of any one of these phases involves the super-addition of something new to the preceding ones. He argues that this notion of God answers all religious requirements, and concludes with a warning and a plea regarding the possibility of future evolution in the light of man's ability to exercise conscious control over events.--K. P. F. (shrink)

As part of a larger research study, we present model language for disclosing financial interests in clinical research to potential research participants, and we describe the empirical basis and theoretical assumptions used in developing the language. The empirical process for creating appropriate disclosure language resulted in a generic disclosure statement for cases in which no risk to participants’ welfare or the scientific integrity of the research is expected, and nine more specific disclosure statements for cases in which some risk is (...) expected. The disclosure statements are not meant to be canonical, but were instead designed to reflect the typical situations in which disclosure of financial interest might be considered by an institutional review board or conflict of interest committee. Individual institutions could modify key phrases to suit their purposes, and others could use the language in future empirical work on informed consent to better refine the options for disclosing financial interests in clinical research. (shrink)

This collection of essays, presented to William Humbert Kane, O.P., founder of the Albertus Magnus Lyceum, has as its principle of unification the notion that the metaphysics and philosophy of nature of Aristotle, Albertus Magnus, and Thomas Aquinas relate directly and importantly--and more than historically--to modern science in all of its aspects. The general reader will probably find that several of the articles illumine for him aspects of the Aristotelian philosophy as much as they do aspects of modern science.--K. P. (...) F. (shrink)

An attempt to come to grips with the problem of how we acquire new concepts or how we develop new theories. Mr. Schon builds his theory on the basis of the idea that we do deal with new situations, or with old situations in new ways, and that we can do so only in terms of "old" theories—concepts which apply literally to other situations. He argues that we do so by "displacing" such concepts, using them as metaphors or projective models (...) for the new situation. This displacement both yields new concepts and conserves old assumptions uncritically. Mr. Schon devotes much attention to the role and nature of the metaphorical use of concepts, yet he fails to develop an explicit theory of their literal use.—K. P. F. (shrink)

While it is primarily a detailed, technical treatise on the principles of the technology of automata, this book does contain some philosophically interesting material. In Part II, devoted to the theoretical construction of robots with consciousness but which exhibit no behavior, Culbertson advances and develops the idea that we can analyze perceptual consciousness in terms of the four dimensional "world-lines" of the transmissions of impulses along neurons, or rather in terms of interconnecting networks of such world lines. In Part III, (...) he argues that consciousness, defined in physical terms, cannot cause behavior. He presents, as an alternative, a doctrine of "historical causation" in which whole extended time periods in the past affect the present—K. P. F. (shrink)